Publications/highlights


29. Tong, Y.*,#, Zhang, J.#, Sun, N.#, Wang, X.#, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F., Zhang, L., Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. (2020). In press.


26. Tong, Y.*, Deng, Z.*, An aurora of natural products-based drug discovery is coming. Synth. Syst. Biotechnol. 5, 92-96. doi: 10.1016/j.synbio.2020.05.003 (2020). Read more…


24. Tong, Y., Whitford, C. M., Blin, K., Jørgensen, T. S., Weber, T.*, Lee, S. Y.* CRISPR-Cas9-based, CRISPRi, and CRISPR-BEST-mediated genetic manipulation in streptomycetes. Nat. Protoc. 15, 2470–2502. doi: 10.1038/s41596-020-0339-z (2020). Read more…


21. Tong, Y., Whitford, C. M., Robertsen, H. L., Blin, K., Jørgensen, T. S., Klitgaard, A. K., Weber, T.*, Lee, S. Y.* Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST. Proc. Natl. Acad. Sci. U.S.A., 116, 20366-20375. doi: 10.1073/pnas.1913493116 (2019). Read more…


19. Palazzotto, E., Tong, Y., Lee, S. Y., Weber, T.* Synthetic biology and metabolic engineering of actinomycetes for natural product discovery. Biotechnol. Adv. 37, 107366. doi: 10.1016/j.biotechadv.2019.03.005 (2019). Read more…


18. Tong, Y., Weber, T.*, Lee, S. Y.* CRISPR/Cas-based genome engineering in natural product discovery. Nat. Prod. Rep. 36, 1262-1280. doi: 10.1039/C8NP00089A (2019). Journal cover paper. Read more…


17. Tong, Y., Robertsen, H. L., Blin, K., Weber, T.*, Lee, S. Y.* CRISPR-Cas9 Toolkit for Actinomycete Genome Editing. Methods Mol. Biol. 1671, 163-184. doi: 10.1007/978-1-4939-7295-1_11 (2018). Read more…


16. Jiang, X., Ellabaan, M. M. H., Charusanti, P., Munck, C., Blin, K., Tong, Y., Weber, T.*, Sommer, M.O.A.*, Lee, S.Y.* Dissemination of antibiotic resistance genes from antibiotic producers to pathogens. Nat. Commun. 8, 15784. doi: 10.1038/ncomms15784 (2017). Read more…


15. Tong, Y.*, Liu, M., Zhang, Y., Liu, X., Huang, R., Song, F., Dai, H., Ren, B., Sun, N., Pei, G., Bian, J., Jia, X-M., Huang, G., Zhou, X., Li, S., Zhang, B., Fukuda, T., Tomoda, H.,Ōmura, S., Cannon, R.D., Calderone, R., Zhang, L.* Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synth. Syst. Biotechnol. 1, 158-168. doi: 10.1016/j.synbio.2016.10.001 (2016). Read more…


13. Tong, Y., Charusanti, P., Zhang, L., Weber, T.*, Lee, S. Y.* CRISPR-Cas9 Based Engineering of Actinomycetal Genomes. ACS Synth. Biol. 4, 1020-1029. doi: 10.1021/acssynbio.5b00038 (2015). Journal cover paper. ESI highly cited paper. Read more…


11. Cui, J., Ren, B., Tong, Y., Dai, H., Zhang, L.* Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence. 6, 362-371. doi: 10.1080/21505594.2015.1039885 (2015). Read more…


10. Tong, Y.# Cao, C.#, Xie, J., Ni, J., Guan, G., Tao, L., Zhang, L., Huang, G.* N-acetylglucosamine-induced white-to-opaque switching in Candida albicans is independent of the Wor2 transcription factor. Fungal Genet. Biol. 62, 71-77. doi: 10.1016/j.fgb.2013.10.005 (2014). Read more...


7. Xie, J.#, Tao, L.#, Nobile, C. J., Tong, Y., Guan, G., Sun, Y., Cao, C., Hernday, A. D., Johnson, A. D., Zhang, L., Bai, F-Y., Huang, G.* White-opaque switching in natural MTLa/α isolates of Candida albicans: evolutionary implications for roles in host adaptation, pathogenesis, and sex. PLoS Biol. 11, e1001525. doi: 10.1371/journal.pbio.1001525 (2013). Read more…


2. Song, F.#, Dai, H.#, Tong, Y.#, Ren, B., Chen, C., Sun, N., Liu, X., Bian, J., Liu, M., Gao, H., Liu, H., Chen, X., Zhang, L.* Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. J. Nat. Prod. 73, 806-810. doi: 10.1021/np900642p (2010). Read more…