Publications

For an up-to-date list of Yaojun’s publications, see his Google Scholar Profile or Research Gate Profile.
*: corresponding author; #: equal contribution


29. Tong, Y.*,#, Zhang, J.#, Sun, N.#, Wang, X.#, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F., Zhang, L., Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. (2020). In press.


28. Tong, Y.* Natural products research in the modern age. Editorial. Synth. Syst. Biotechnol. 5, 314-315. doi: 10.1016/j.synbio.2020.09.001 (2020). Read more…


27. Zhao, X., Li, S., Liu, G., Wang, Z., Yang, Z., Zhang, Q., Liang, M., Liu, J., Li, Z., Tong, Y., Zhu, G., Wang, X., Jiang, L., Wang, W.*, Tan, G.Y.*, Zhang, L.* A versatile biosensing platform coupling CRISPR–Cas12a and aptamers for detection of diverse analytes. Science Bulletin. doi: 10.1016/j.scib.2020.09.004 (2020). Read more…


26. Tong, Y.*, Deng, Z.*, An aurora of natural products-based drug discovery is coming. Synth. Syst. Biotechnol. 5, 92-96. doi: 10.1016/j.synbio.2020.05.003 (2020). Read more…


25. Blin, K., Shaw, S., Tong, Y., Weber, T.* Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0. Synth. Syst. Biotechnol. 5, 99-102. doi: 10.1016/j.synbio.2020.05.005 (2020). Read more…


24. Tong, Y., Whitford, C. M., Blin, K., Jørgensen, T. S., Weber, T.*, Lee, S. Y.* CRISPR-Cas9-based, CRISPRi, and CRISPR-BEST-mediated genetic manipulation in streptomycetes. Nat. Protoc. 15, 2470–2502. doi: 10.1038/s41596-020-0339-z (2020). Read more…


23. Jakočiūnas, T.*, Klitgaard, A. K., Kontou, E. E., Nielsen, J.B., Thomsen, E., Romero-Suarez, D., Blin, K., Petzold, C. J., Gin, J. W., Tong, Y., Gotfredsen, C. H., Charusanti, P., Frandsen, R. J. N., Weber, T., Lee, S. Y., Jensen, M. K., Keasling, J. D.* Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast. Synth. Syst. Biotechnol. 5, 11-18. doi: 10.1016/j.synbio.2020.01.004 (2020). Read more…


22. Wang, Q., Xie, F., Tong, Y., Habisch, R., Yang, B., Zhang, L.*, Müller, R.*, Fu, C.* Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes. Appl. Microbiol. Biotechnol. 104, 225-239. doi: 10.1007/s00253-019-10223-4 (2020). Read more…


21. Tong, Y., Whitford, C. M., Robertsen, H. L., Blin, K., Jørgensen, T. S., Klitgaard, A. K., Weber, T.*, Lee, S. Y.* Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST. Proc. Natl. Acad. Sci. U.S.A., 116, 20366-20375. doi: 10.1073/pnas.1913493116 (2019). Read more…


20. Liang, M., Li, Z., Wang, W., Liu, J., Liu, L., Zhu, G., Karthik, L., Wang, M., Wang, K-F., Wang, Z., Yu, J., Shuai, Y., Yu, J., Zhang, L., Yang, Z., Li, C., Zhang, Q., Shi, T., Zhou, L., Xie, F., Dai, H., Liu, X., Zhang, J., Liu, G., Zhuo, Y., Zhang, B., Liu, C., Li, S., Xia, X., Tong, Y., Liu, Y., Alterovitz, G., Tan, G-Y.*, Zhang, L.* A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nat. Commun. 10, 3672. doi: 10.1038/s41467-019-11648-1 (2019).  Read more…


19. Palazzotto, E., Tong, Y., Lee, S. Y., Weber, T.* Synthetic biology and metabolic engineering of actinomycetes for natural product discovery. Biotechnol. Adv. 37, 107366. doi: 10.1016/j.biotechadv.2019.03.005 (2019). Read more…


18. Tong, Y., Weber, T.*, Lee, S. Y.* CRISPR/Cas-based genome engineering in natural product discovery. Nat. Prod. Rep. 36, 1262-1280. doi: 10.1039/C8NP00089A (2019). Journal cover paper. Read more…


17. Tong, Y., Robertsen, H. L., Blin, K., Weber, T.*, Lee, S. Y.* CRISPR-Cas9 Toolkit for Actinomycete Genome Editing. Methods Mol. Biol. 1671, 163-184. doi: 10.1007/978-1-4939-7295-1_11 (2018). Read more…


16. Jiang, X., Ellabaan, M. M. H., Charusanti, P., Munck, C., Blin, K., Tong, Y., Weber, T.*, Sommer, M.O.A.*, Lee, S.Y.* Dissemination of antibiotic resistance genes from antibiotic producers to pathogens. Nat. Commun. 8, 15784. doi: 10.1038/ncomms15784 (2017). Read more…


15. Tong, Y.*, Liu, M., Zhang, Y., Liu, X., Huang, R., Song, F., Dai, H., Ren, B., Sun, N., Pei, G., Bian, J., Jia, X-M., Huang, G., Zhou, X., Li, S., Zhang, B., Fukuda, T., Tomoda, H.,Ōmura, S., Cannon, R.D., Calderone, R., Zhang, L.* Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synth. Syst. Biotechnol. 1, 158-168. doi: 10.1016/j.synbio.2016.10.001 (2016). Read more…


14. Weber, T.*, Tong, Y., Blin, K., Lee, S. Y. Engineering of actinomycetes using CRISPR/Cas9 technologies. Planta Medica. 81, S01. doi: 10.1055/s-0036-1596147 (2016). Read more...


13. Tong, Y., Charusanti, P., Zhang, L., Weber, T.*, Lee, S. Y.* CRISPR-Cas9 Based Engineering of Actinomycetal Genomes. ACS Synth. Biol. 4, 1020-1029. doi: 10.1021/acssynbio.5b00038 (2015). Journal cover paper. ESI highly cited paper. Read more…


12. Weber, T., Charusanti, P., Musiol-Kroll, E. M., Jiang, X., Tong, Y., Kim, H. U., Lee, S. Y.* Metabolic engineering of antibiotic factories: New tools for antibiotic production in actinomycetes. Trends Biotechnol. 33(1), 15-26. doi: 10.1016/j.tibtech.2014.10.009 (2015). Journal cover paper. Read more…


11. Cui, J., Ren, B., Tong, Y., Dai, H., Zhang, L.* Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence. 6, 362-371. doi: 10.1080/21505594.2015.1039885 (2015). Read more…


10. Tong, Y.# Cao, C.#, Xie, J., Ni, J., Guan, G., Tao, L., Zhang, L., Huang, G.* N-acetylglucosamine-induced white-to-opaque switching in Candida albicans is independent of the Wor2 transcription factor. Fungal Genet. Biol. 62, 71-77. doi: 10.1016/j.fgb.2013.10.005 (2014). Read more...


9. Zhang, H. M., Dai, H., Hanson, P. J., Li, H., Guo, H., Ye, X., Hemida, M. G., Wang, L., Tong, Y., Qiu, Y., Liu, S., Wang, F., Song, F., Zhang, B., Wang, J.*, Zhang, L.*, Yang, D.* Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation. ACS Chem. Biol. 18, 9(4), 1015-1024. doi: 10.1021/cb400775z (2014). Read more…


8. Ren, B., Dai, H., Pei, G., Tong, Y., Zhuo, Y., Yang, N., Su, M., Huang, P., Yang, Y., Zhang. L.* ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility. Appl. Microbiol. Biotechnol. 98(6), 2609-2616. doi: 10.1007/s00253-013-5425-5 (2014).  Read more…


7. Xie, J.#, Tao, L.#, Nobile, C. J., Tong, Y., Guan, G., Sun, Y., Cao, C., Hernday, A. D., Johnson, A. D., Zhang, L., Bai, F-Y., Huang, G.* White-opaque switching in natural MTLa/α isolates of Candida albicans: evolutionary implications for roles in host adaptation, pathogenesis, and sex. PLoS Biol. 11, e1001525. doi: 10.1371/journal.pbio.1001525 (2013). Read more…


6. Guan, G., Xie, J., Tao, L., Nobile, C. J., Sun, Y., Cao, C., Tong, Y., Huang, G.* Bcr1 plays a central role in the regulation of opaque cell filamentation in Candida albicans. Mol. Microbiol. 89, 732-750. doi: 10.1111/mmi.12310 (2013). Read more…


5. Du, H., Guan, G., Xie, J., Sun, Y., Tong, Y., Zhang, L., Huang, G.* Roles of Candida albicans Gat2, a GATA-type zinc finger transcription factor, in biofilm formation, filamentous growth and virulence. PLoS One. 7(1), e29707. doi: 10.1371/journal.pone.0029707 (2012). Read more…


4. Xie, J., Du, H., Guan, G., Tong, Y., Kourkoumpetis, T., Zhang, L., Bai, F-Y., Huang, G.* N-acetylglucosamine induces white-to-opaque switching and mating in Candida tropicalis providing new insights into adaptation and fungal sexual evolution. Eukaryot. Cell. 11(6), 773-782. doi: 10.1128/EC.00047-12 (2012). Read more…


3. Song, F., Ren, B., Yu, K., Chen, C., Guo, H., Yang, N., Gao, H., Liu, X., Liu, M., Tong, Y., Dai, H., Bai, H., Wang, J., Zhang, L.* Quinazolin-4-one coupled with pyrrolidin-2-iminium alkaloids from marine-derived fungus Penicillium aurantiogriseum. Mar. Drugs. 10(6), 1297-1306. doi: 10.3390/md10061297 (2012). Read more…


2. Song, F.#, Dai, H.#, Tong, Y.#, Ren, B., Chen, C., Sun, N., Liu, X., Bian, J., Liu, M., Gao, H., Liu, H., Chen, X., Zhang, L.* Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. J. Nat. Prod. 73, 806-810. doi: 10.1021/np900642p (2010). Read more…


1. 陈明, 任彪, 童垚俊, 张立新, 互动药物研究现状与发展态势。生物产业技术,06,49-54. doi: 10.3969/j.issn.1674-0319.2010.06.007 (2010).